-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine tert-Butyl Ester
Fmoc-Ser-Otbu
CAS: 110797-35-8
Molecular Formula: C22H25NO5
-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine tert-Butyl Ester - Names and Identifiers
-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine tert-Butyl Ester - Physico-chemical Properties
| Molecular Formula | C22H25NO5 |
| Molar Mass | 383.44 |
| Density | 1.216±0.06 g/cm3(Predicted) |
| Melting Point | 127 °C |
| Boling Point | 588.4±45.0 °C(Predicted) |
| pKa | 10.07±0.46(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 11 ° (C=1, CHCl3) |
-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine tert-Butyl Ester - Reference Information
| Application | N-(9-fluorenylmethoxycarbonyl) L-serine tert-butyl ester is an important starting reactant in the synthesis of polypeptides, which is widely used in the synthesis of polypeptides. |
| preparation | L-serine tert-butyl ester was added to a round bottom flask, and a 10% aqueous solution of sodium carbonate was added and dissolved with stirring, then dioxane is added, and 10% dioxane solution of 9-fluorenylmethoxycarbonyl chloride is slowly added dropwise into the reaction solution in an ice bath, and the reaction is carried out in an ice bath for 2 hours after completion of the dropwise addition, then react at room temperature for 8 hours, dilute with water, extract with ether 4 times, place the water layer in ice bath, adjust the pH value with concentrated hydrochloric acid to Congo red test paper, in the refrigerator overnight, the white precipitate was extracted with ethyl acetate, the combined organic liquid was washed with water, the organic layer was dried with anhydrous magnesium sulfate, and the product N-(9-fluorenylmethoxycarbonyl) was obtained.-L-serine tert-butyl ester. |
Last Update：2024-04-09 15:16:40
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